Biocorium, A Unique and Pioneering Expertise in Biotechnology

Reinventing Cosmetics

Biocorium, a French pioneer of Biofermentation-4D, brings natural beauty back to life.

Biofermentation

The 4 Pillars of the Biofermentation-4D Process

DIVERSITY

Unique symbiotic consortium of ferments

SUSTAINABILITY

Eco-friendly, stable, and GMO-free process

DEPLOYMENT

Flexible method adaptable to all plants

DYNAMIC

Ferments organized in a 3D biomatrix + Time

A process that reveals nature’s potential

Biocorium is a pioneering French laboratory and creator of Biofermentation-4D, an innovative biotechnology that revitalizes natural cosmetics by harnessing the living power of proprietary symbiotic ferments.

Plants are naturally rich in active molecules. However, a large part of these treasures remains locked within their structure, difficult to access and scarcely available to the skin. At Biocorium, we unlock this potential.

Carefully associated with each plant and supported by rigorous traceability, our symbiotically organized ferments act in several phases over time within a three-dimensional plant environment.

This collective intelligence enables them to work together like an orchestra, whose harmony is supervised by Biocorium, transforming plants by sustainably releasing their valuable active compounds.

This community of ferments, which we call Celluzium®, begins by removing unnecessary compounds such as sugars that trap active molecules, then reveals, transforms, and stabilizes valuable compounds such as polyphenols and flavonoids that were previously inaccessible.

We therefore obtain a new generation of fermented botanical active ingredients: richer, more bioavailable, and more effective for the skin, inspired by the subtle balances of natural ecosystems. Biocorium thus establishes itself as the conductor of this unique microbiofactory. A perfect balance between science and nature.

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Celluzium® and Prébiosomes®

The proprietary living biomatrix that reveals active ingredients

A living structure orchestrated by Biocorium for an effective and sustainable cosmetic symphony

At the heart of Biofermentation-4D lies Celluzium®, the solid and living biomatrix formed through the skillful association, designed and optimized by Biocorium, of proprietary ferments.

Each microorganism contributes complementary functions. These ferments organize themselves in interdependence, acting as a single organism through their collective intelligence mastered by Biocorium. Together, they break down plant structures, release natural active ingredients, and generate new bioactive metabolites.

This symbiotic work enables controlled and reproducible production. This is the strength of Biofermentation-4D.

Prébiosomes®, a new generation of bio-fermented active ingredients, result from this natural activity. They are natural complexes where polyphenols and soluble exopolysaccharides (soluble EPS) combine to protect, carry, and regulate the bioavailability of active ingredients.

This natural organization improves active ingredient stability, reduces degradation (oxidation, hydrolysis, heat), and enables progressive release that optimizes efficacy and skin tolerance while respecting the microbiome. Unlike artificial encapsulation techniques, our technology offers a sustainable biomimetic approach without chemical additives.

Celluzium® and Prébiosomes® demonstrate how mastering microbial symbiosis and the intelligent transformation of plants can provide powerful skincare solutions that respect both the skin and the environment, bringing natural cosmetics into a new era.

They promote skin resilience, renewal, and natural radiance. They improve microcirculation, facilitating the delivery of oxygen and essential nutrients.

Through this exclusive innovation, Biocorium combines scientific rigor with living intelligence to create signature cosmetic ingredients for the cosmetics of tomorrow.

schéma biocorium celluzium

This fermented biomatrix acts on several levels:

Stimulates skin defense through its prebiotic effect

Enriches the skin with highly bioavailable fermented nutrients

Restarts cellular respiration and metabolic energy production

100% plant-based

Guaranteed free from synthetic or animal-derived inputs – GMO-free

Traceability

Traceability from bioferment to finished product

Unique Ingredients

Unique phyto-fermentation process using proprietary bioferments

Eco-responsible Process

Responsible use of renewable resources

Production in France

From research to production, from bioferments to active ingredients, in France (Toulouse)

Case Study

Guerlain Renew & Repair – Polyfermentation Applied to Two Rare Honeys

Biocorium Guerlain Abeille Royale

Guerlain – Renew & Repair: Polyfermentation at the Heart of Regeneration

Enhancing two rare honeys through an innovative biotechnological process

For its Abeille Royale – Double R Renew & Repair range, Guerlain chose to rely on Biocorium’s expertise, which developed a custom polyfermentation process applied to two exceptional honeys sourced from the preserved regions of Ouessant and Ikaria.

Two patents protect these fermented ingredients, reflecting the brand’s commitment to ethics, naturality, and innovation.

Biocorium designed an exclusive technology using a consortium of ten microorganisms capable of generating more than 30% new active molecules, thereby increasing the ability of the honeys to protect, repair, and strengthen the skin against daily aggressions. Integrated into the combination of the four honeys and royal jelly within the range, these polyferments enhance skin regeneration and optimize cellular communication. The technology also guarantees batch reproducibility and compliance with Guerlain’s strict quality and sustainability requirements.

How Can the Biocorium Laboratory Transform Your Cosmetic Formulations?

We answer your questions

We primarily enhance organic, local, and French plants, or those sourced from sustainable agriculture. Our process can be adapted to a wide variety of plants, offering flexibility and customization for your products.

Yes. Our ingredients are designed to be compatible and complementary, allowing the creation of tailor-made formulations with multiple targeted effects (hydration, radiance, anti-aging, etc.).

Water is a precious resource. At Biocorium, enhancing its value is at the heart of our DNA. Instead of discarding process water, we transform it into bioactive water, integrating it into formulations and providing genuine added value. For example, up to 94% of the water used in the process becomes bioactive, reducing waste and optimizing resource use.

Our bioactive waters are produced in-house in Toulouse, France, under strict controls at every stage. Fermentation and formulation processes are optimized to ensure safety, stability, and reproducibility.